Article
The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes.
Investigative ophthalmology & visual science - 1 Jan 2012
Mattapallil Mary J, Wawrousek Eric F, Chan Chi-Chao, Zhao Hui, Roychoudhury Jayeeta, Ferguson Thomas A, Caspi Rachel R
Abstract excerpt
PURPOSE: We noted an unexpected inheritance pattern of lesions in several strains of gene-manipulated mice with ocular phenotypes. The lesions, which appeared at various stages of backcross to C57BL/6, bore resemblance to the rd8 retinal degeneration phenotype. We set out to examine the prevalence of this mutation in induced mutant mouse lines, vendor C57BL/6 mice and in widely used embryonic stem cells. METHODS:...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.