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Article

Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair.

Investigative ophthalmology & visual science - 20 Jan 2014

Low Benjamin E, Krebs Mark P, Joung J Keith, Tsai Shengdar Q, Nishina Patsy M, Wiles Michael V

Abstract excerpt

PURPOSE: We directly corrected the mouse Crb1(rd8) gene mutation, which is present in many inbred laboratory strains derived from C57BL/6N and complicates genetic studies of retinal disease in mice. METHODS: Fertilized C57BL/6NJ oocytes were coinjected with mRNAs encoding a transcription activator-like effector nuclease (TALEN) targeting the Crb1(rd8) allele plus single-stranded oligonucleotides to correct the...

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Identifiers

PMID: 24346171
DOI: 10.1167/iovs.13-13278
PMCID: PMC3921157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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