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Article

Loss of caveolin-1 causes blood-retinal barrier breakdown, venous enlargement, and mural cell alteration.

The American journal of pathology - 1 Feb 2014

Gu Xiaowu, Fliesler Steven J, Zhao You-Yang, Stallcup William B, Cohen Alex W, Elliott Michael H

Abstract excerpt

Blood-retinal barrier (BRB) breakdown and related vascular changes are implicated in several ocular diseases. The molecules and mechanisms regulating BRB integrity and pathophysiology are not fully elucidated. Caveolin-1 (Cav-1) ablation results in loss of caveolae and microvascular pathologies, but the role of Cav-1 in the retina is largely unknown. We examined BRB integrity and vasculature in Cav-1 knockout...

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Identifiers

PMID: 24326256
DOI: 10.1016/j.ajpath.2013.10.022
PMCID: PMC3906491

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