Article

Alzheimer’s genetic risk factor <i>FERMT2</i> (Kindlin-2) controls axonal growth and synaptic plasticity in an APP-dependent manner

2019-09-13

Abstract excerpt

<h4>ABSTRACT</h4> Although APP metabolism is being intensively investigated, a large fraction of its modulators are yet to be characterized. In this context, we combined two genome-wide high-content screenings to assess the functional impact of miRNAs and genes on APP metabolism and the signaling pathways involved. This approach highlighted the involvement of FERMT2 (or Kindlin-2), a genetic risk factor of Alzhe...

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Literature Corpus work: e9317be8-c95b-51fc-8ed9-d71de99e3c3d
DOI: 10.1101/767194

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