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Article

Interplay between the DNA Damage Response and Immunotherapy Response in Cancer

1 Nov 2022

Abstract excerpt

Genome instability and immune evasion are both defining hallmarks of cancer. Tumorigenesis is frequently initiated when there is DNA damage to a proto-oncogene or tumor suppressor gene and DNA repair mechanisms are lost or insufficient to correct the damage; immune evasion then prevents the host immune system from recognizing these transformed cells. Therapies targeting genomic instability and immune evasion have...

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PMID: 36362142
DOI: 10.3390/ijms232113356

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