Article
A large-scale integrative analysis of GWAS and common meQTLs across whole life course identifies genes, pathways and tissue/cell types for three major psychiatric disorders.
Neuroscience and biobehavioral reviews - 1 Dec 2018
Zhao Yan, Liang Xiao, Zhu Feng, Wen Yan, Xu Jiawen, Yang Jian, Ding Miao, Cheng Bolun, Ma Mei, Zhang Lu, Cheng Shiqiang, Wu Cuiyan, Wang Sen, Wang Xi, Ning Yujie, Guo Xiong, Zhang Feng
Abstract excerpt
Attention deficit hyperactivity disorder (ADHD), bipolar disorder (BP) and schizophrenia (SCZ) are complex psychiatric disorders. We conducted a large-scale integrative analysis of genome-wide association studies (GWAS) and life course consistent methylation quantitative trait loci (meQTLs) datasets. The GWAS data of ADHD (including 20,183 cases and 35,191 controls), BP (including 7481 cases and 9250 controls)...
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