Article
Genome-wide analyses of ADHD identify 27 risk loci, refine the genetic architecture and implicate several cognitive domains.
Nature genetics - 1 Feb 2023
Demontis Ditte, Walters G Bragi, Athanasiadis Georgios, Walters Raymond, Therrien Karen, Nielsen Trine Tollerup, Farajzadeh Leila, Voloudakis Georgios, Bendl Jaroslav, Zeng Biau, Zhang Wen, Grove Jakob, Als Thomas D, Duan Jinjie, Satterstrom F Kyle, Bybjerg-Grauholm Jonas, Bækved-Hansen Marie, Gudmundsson Olafur O, Magnusson Sigurdur H, Baldursson Gisli, Davidsdottir Katrin, Haraldsdottir Gyda S, Agerbo Esben, Hoffman Gabriel E, Dalsgaard Søren, Martin Joanna, Ribasés Marta, Boomsma Dorret I, Soler Artigas Maria, Roth Mota Nina, Howrigan Daniel, Medland Sarah E, Zayats Tetyana, Rajagopal Veera M, Nordentoft Merete, Mors Ole, Hougaard David M, Mortensen Preben Bo, Daly Mark J, Faraone Stephen V, Stefansson Hreinn, Roussos Panos, Franke Barbara, Werge Thomas, Neale Benjamin M, Stefansson Kari, Børglum Anders D
Abstract excerpt
Attention-deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder with a major genetic component. Here, we present a genome-wide association study meta-analysis of ADHD comprising 38,691 individuals with ADHD and 186,843 controls. We identified 27 genome-wide significant loci, highlighting 76 potential risk genes enriched among genes expressed particularly in early brain development....
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