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Article

FOXO Transcription Factors Control E2F1 Transcriptional Specificity and Apoptotic Function

22 Aug 2013

Abstract excerpt

The transcription factor E2F1 is a key regulator of proliferation and apoptosis but the molecular mechanisms that mediate these cell fate decisions remain unclear. Here, we identify FOXO transcription factors as E2F1 target genes that act in a feed-forward regulatory loop to reinforce gene induction of multiple apoptotic genes. We found that E2F1 forms a complex with FOXO1 and FOXO3. RNAi-mediated silencing of...

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PMID: 23966291
DOI: 10.1158/0008-5472.can-13-0453

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