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Alzheimer’s Disease DNA Methylome of Pyramidal Layers in Frontal Cortex: Laser-Assisted Microdissection Study

16 Oct 2018

Abstract excerpt

OBJECTIVE: To study DNA methylation patterns of cortical pyramidal layers susceptible to late-onset Alzheimer's disease (LOAD) neurodegeneration. METHODS: Laser-assisted microdissection to select pyramidal layers' cells in frontal cortex of 32 human brains (18 LOAD) and Infinium DNA Methylation 450K analysis were performed to find differential methylated positions and regions, in addition to the corresponding...

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PMID: 30324800
DOI: 10.2217/epi-2017-0160

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