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Nanoengineered, cell-derived extracellular matrix influences ECM-related gene expression of mesenchymal stem cells

5 Oct 2018

Abstract excerpt

BACKGROUND: Human mesenchymal stem cells (hMSCs) are, due to their pluripotency, useful sources of cells for stem cell therapy and tissue regeneration. The phenotypes of hMSCs are strongly influenced by their microenvironment, in particular the extracellular matrix (ECM), the composition and structure of which are important in regulating stem cell fate. In reciprocal manner, the properties of ECM are remodeled by...

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PMID: 30323947
DOI: 10.1186/s40824-018-0141-y

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