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Nanotopographical control of human embryonic stem cell differentiation into definitive endoderm

22 Apr 2015

Abstract excerpt

Derivation of definitive endoderm (DE) from human embryonic stem cells (hESCs) can address the needs of regenerative medicine for endoderm-derived organs such as the pancreas and liver. Fibrous substrates which topographically recapitulate native extracellular matrix have been known to promote the stem cell differentiation. However, the optimal fiber diameter remains to be determined for the desired...

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PMID: 25907898
DOI: 10.1002/jbm.a.35483

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