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Article

Protein ligand and nanotopography separately drive the phenotype of mouse embryonic stem cells.

Biomaterials - 1 Oct 2023

Ghorbani Sadegh, Christine Füchtbauer Annette, Møllebjerg Andreas, Møller Martensen Pia, Hvidbjerg Laursen Sara, Christian Evar Kraft David, Kjems Jørgen, Meyer Rikke Louise, Rahimi Karim, Foss Morten, Füchtbauer Ernst-Martin, Sutherland Duncan S

Abstract excerpt

Biochemical and biomechanical signals regulate stem cell function in the niche environments in vivo. Current in vitro culture of mouse embryonic stem cells (mESC) uses laminin (LN-511) to provide mimetic biochemical signaling (LN-521 for human systems) to maintain stemness. Alternative approaches propose topographical cues to provide biomechanical cues, however combined biochemical and topographic cues may better...

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PMID: 37459700
DOI: 10.1016/j.biomaterials.2023.122244

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