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Article

Induction of predominant tenogenic phenotype in human dermal fibroblasts via synergistic effect of TGF-β and elongated cell shape.

American journal of physiology. Cell physiology - 1 Mar 2016

Wang Wenbo, Li Jie, Wang Keyun, Zhang Zhiyong, Zhang Wenjie, Zhou Guangdong, Cao Yilin, Ye Mingliang, Zou Hanfa, Liu Wei

Abstract excerpt

Micropattern topography is widely investigated for its role in mediating stem cell differentiation, but remains unexplored for phenotype switch between mature cell types. This study investigated the potential of inducing tenogenic phenotype in human dermal fibroblasts (hDFs) by artificial elongation of cultured cells. Our results showed that a parallel microgrooved topography could convert spread hDFs into an...

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Identifiers

PMID: 26632599
DOI: 10.1152/ajpcell.00300.2015

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