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Article

The Role of TAM Family Receptors in Immune Cell Function: Implications for Cancer Therapy

21 Oct 2016

Abstract excerpt

The TAM receptor protein tyrosine kinases-Tyro3, Axl, and Mer-are essential regulators of immune homeostasis. Guided by their cognate ligands Growth arrest-specific gene 6 (Gas6) and Protein S (Pros1), these receptors ensure the resolution of inflammation by dampening the activation of innate cells as well as by restoring tissue function through promotion of tissue repair and clearance of apoptotic cells. Their...

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PMID: 27775650
DOI: 10.3390/cancers8100097

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