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CDT2‐controlled cell cycle reentry regulates the pathogenesis of Alzheimer's disease

12 Oct 2018

Abstract excerpt

INTRODUCTION: Altered cell cycle reentry has been observed in Alzheimer's disease (AD). Denticleless (DTL) was predicted as the top driver of a cell cycle subnetwork associated with AD. METHODS: We systematically investigated DTL expression in AD and studied the molecular, cellular, and behavioral endophenotypes triggered by DTL overexpression. RESULTS: We experimentally validated that CDT2, the protein encoded...

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PMID: 30321504
DOI: 10.1016/j.jalz.2018.08.013

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