Article

Germline Functional Variants Contribute to Somatic Mutation and Outcomes in Neuroblastoma

2023-06-28

Abstract excerpt

<title>Abstract</title> <p>Germline genetic context may play a significant role in the development and evolution of cancer, particularly in childhood cancers such as neuroblastoma. We studied the role of putatively functional germline variants (pFGVs) in neuroblastoma, even if they do not directly increase disease risk. Our whole-exome sequencing analysis of 125 patients with neuroblastoma revealed a positive cor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70cd1693-30ea-5616-8f19-3067125284f3
DOI: 10.21203/rs.3.rs-3037031/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Germline Functional Variants Contribute to Somatic Mutation and Outcomes in NeuroblastomaDOI 10.21203/rs.3.rs-3037031/v1Read

Germline functional variants contribute to somatic mutation and outcomes in neuroblastoma.Semantic proximity Read

Germline pathogenic variants in 786 neuroblastoma patientsSemantic proximity Read

Whole-exome sequencing reveals genetic variants in low-risk and high-risk neuroblastomaSemantic proximity Read

Rare germline structural variants increase risk for pediatric solid tumorsSemantic proximity Read

Genetic susceptibility to neuroblastoma: current knowledge and future directions.Semantic proximity Read

Rare germline structural variants increase risk for pediatric solid tumors.Semantic proximity Read

Pharmacogenetics in Neuroblastoma: What Can Already Be Clinically Implemented and What Is Coming Next?Semantic proximity Read

Germline pathogenic variants in neuroblastoma patients are enriched in BARD1 and predict worse survival.Semantic proximity Read

The genetic landscape of high-risk neuroblastoma.Semantic proximity Read

Genetic Predisposition to NeuroblastomaSemantic proximity Read

Whole exome sequencing identified sixty-five coding mutations in four neuroblastoma tumors.Semantic proximity Read

Advances in the understanding of constitutional and somatic genomic alterations in neuroblastoma.Semantic proximity Read