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Specific differences and novel key regulatory genes of sex in influencing exceptional longevity phenotypes.

Diabetes & metabolic syndrome - 1 May 2024

Ni Xiaolin, Su Huabin, Li Gong-Hua, Li Rongqiao, Lan Rushu, Lv Yuan, Pang Guofang, Zhang Wei, Yang Ze, Hu Caiyou

Abstract excerpt

BACKGROUND AND AIMS: Although the life expectancy of women systematically and robustly exceeds that of men, specific differences and molecular mechanisms of sex in influencing longevity phenotypes remain largely unknown. Therefore, we performed transcriptome sequencing of peripheral blood samples to explore regulatory mechanisms of healthy longevity by incorporating sex data. METHODS: We selected 34 exceptional...

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PMID: 38762968
DOI: 10.1016/j.dsx.2024.103039

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