Article
Genomic analysis in myeloid sarcoma and comparison with paired acute myeloid leukemia.
Human pathology - 1 Feb 2021
Greenland Nancy Y, Van Ziffle Jessica A, Liu Yen-Chun, Qi Zhongxia, Prakash Sonam, Wang Linlin
Abstract excerpt
Myeloid sarcoma (MS) is a rare manifestation of acute myeloid leukemia (AML) characterized by extramedullary proliferation of myeloid blasts. Owing to the rarity of MS, the clonal evolution of cell populations giving rise to MS is not well understood. To study the genomic signature of MS, we used a capture-based next-generation sequencing panel targeting 479 cancer genes to interrogate the genetic variants...
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