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Mapping of the Lassa virus LAMP1 binding site reveals unique determinants not shared by other old world arenaviruses

27 Apr 2017

Abstract excerpt

Cell entry of many enveloped viruses occurs by engagement with cellular receptors, followed by internalization into endocytic compartments and pH-induced membrane fusion. A previously unnoticed step of receptor switching was found to be critical during cell entry of two devastating human pathogens: Ebola and Lassa viruses. Our recent studies revealed the functional role of receptor switching to LAMP1 for...

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PMID: 28448640
DOI: 10.1371/journal.ppat.1006337

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