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Novel Naphthalene-Based Inhibitors of Trypanosoma brucei RNA Editing Ligase 1

24 Aug 2010

Abstract excerpt

BACKGROUND: Neglected tropical diseases, including diseases caused by trypanosomatid parasites such as Trypanosoma brucei, cost tens of millions of disability-adjusted life-years annually. As the current treatments for African trypanosomiasis and other similar infections are limited, new therapeutics are urgently needed. RNA Editing Ligase 1 (REL1), a protein unique to trypanosomes and other kinetoplastids, was...

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PMID: 20808768
DOI: 10.1371/journal.pntd.0000803

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