Genetic risk score (GRS) constructed from polymorphisms in the PON1, IL-6, ITGB3, and ALDH2 genes is associated with the risk of coronary artery disease in Pakistani subjects

Abstract excerpt

Coronary artery disease (CAD) is a major killer in today’s world. Pakistan is also affected by this non-communicable disease like other countries. It is a multifactorial disease and is influenced by many gene-gene and gene-environment interactions. A total of 623 (219 controls, 404 cases) Pakistani subjects were genotyped for four SNPs, rs662 ( PON1 ), rs5918 ( ITGB3 ), rs671 ( ALDH2 ), rs1800795 ( IL-6 ) by...