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Identifying genetic susceptibility loci associated with human coronary artery disease

9 Jan 2025

Abstract excerpt

Coronary artery disease (CAD) is a multigenic condition influenced by both nature and nurture (60% to 40%). Prognosis of CAD is based on familial patterns. This study examined and analyzed the susceptibility of CAD to genetic variants in various Pakistani families. A total of 50 families, 308 participants (79 affected and 229 unaffected were genotyped for NOS3 (rs1799983, rs2070744), PON1 (rs662), LPA-PLA2...

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PMID: 39787106
DOI: 10.1371/journal.pone.0315460

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