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Article

DNA methylation profiling is a method of choice for molecular verification of pediatric WNT-activated medulloblastomas

19 Sept 2018

Abstract excerpt

BACKGROUND: Wingless-activated medulloblastoma (WNT MB) represents a well-characterized molecular variant accounting for 10-15% of all MB and is associated with a favorable clinical outcome. Patients with localized WNT MBs could benefit from de-intensification of combined treatment, which would require an accurate diagnosis of these tumors. However, despite the presence of molecular features related with a WNT MB...

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PMID: 30252101
DOI: 10.1093/neuonc/noy155

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