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Methylation Profiling of Medulloblastoma in a Clinical Setting Permits Sub-classification and Reveals New Outcome Predictions

20 Mar 2020

Abstract excerpt

Medulloblastoma (MB) is the most common childhood malignant brain tumor and a leading cause of cancer-related death in children. DNA methylation profiling has rapidly advanced our understanding of MB pathogenesis at the molecular level, but assessments in Saudi Arabian (SA)-MB cases are sparse. MBs can be sub-grouped according to methylation patterns from FPPE samples into Wingless (WNT-MB), Sonic Hedgehog...

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PMID: 32265819
DOI: 10.3389/fneur.2020.00167

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