Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization.

Journal of virology - 1 Oct 2008

Stenglein Mark D, Matsuo Hiroshi, Harris Reuben S

Abstract excerpt

APOBEC3G limits the replication of human immunodeficiency virus type 1, other retroviruses, and retrotransposons. It localizes predominantly to the cytoplasm of cells, which is consistent with a model wherein cytosolic APOBEC3G packages into assembling virions, where it exerts its antiviral effect by deaminating viral cDNA cytosines during reverse transcription. To define the domains of APOBEC3G that determine...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Amino Acid Motifs
Share to APOBEC-3G Deaminase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Nucleus

Share to Cytidine Deaminase

Share to Cytoplasm

Share to Gene Expression Regulation, Viral

Share to HeLa Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 18667511
DOI: 10.1128/JVI.02471-07
PMCID: PMC2546964

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two regions within the amino-terminal half of APOBEC3G cooperate to determine cytoplasmic localization.PMID 18667511Read ↗

Polymorphism in human APOBEC3H affects a phenotype dominant for subcellular localization and antiviral activity.Semantic proximity Read ↗

APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for RestrictionSemantic proximity Read ↗

Nuclear Exclusion of the HIV-1 Host Defense Factor APOBEC3G Requires a Novel Cytoplasmic Retention Signal and Is Not Dependent on RNA BindingSemantic proximity Read ↗

APOBEC3B Nuclear Localization Requires Two Distinct N-Terminal Domain Surfaces.Semantic proximity Read ↗

Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate SpeciesSemantic proximity Read ↗

Analysis of HIV-1 viral infectivity factor-mediated proteasome-dependent depletion of APOBEC3G: correlating function and subcellular localization.Semantic proximity Read ↗

Extensive mutagenesis experiments corroborate a structural model for the DNA deaminase domain of APOBEC3G.Semantic proximity Read ↗

Human Immunodeficiency Virus Type 1 Vif Functionally Interacts with Diverse APOBEC3 Cytidine Deaminases and Moves with Them between Cytoplasmic Sites of mRNA MetabolismSemantic proximity Read ↗

Nucleolar localization of non-structural protein 3b, a protein specifically encoded by the severe acute respiratory syndrome coronavirusSemantic proximity Read ↗

Identification of residues within the L2 region of rhesus TRIM5alpha that are required for retroviral restriction and cytoplasmic body localization.Semantic proximity Read ↗

Human cytomegalovirus mediates APOBEC3B relocalization early during infection through a ribonucleotide reductase-independent mechanismSemantic proximity Read ↗

Identification of Amino Acid Residues in APOBEC3G Required for Regulation by Human Immunodeficiency Virus Type 1 Vif and Virion EncapsidationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.