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Article

Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNA.

Nature - 1 Jan 2000

Schaufele F, Gilmartin G M, Bannwarth W, Birnstiel M L

Abstract excerpt

Processing of the 3' end of sea urchin H3 histone pre-mRNA requires conserved sequence elements and the presence of U7 snRNA. A mutation in the conserved CAAGAAGA sequence of the H3 pre-mRNA that renders 3' processing of this precursor defective is shown to be suppressed by a compensatory change in the U7 snRNA, restoring the base-pairing potential of the two RNAs. RNA-RNA contacts between these two molecules...

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Source

Identifiers

PMID: 3022153
DOI: 10.1038/323777a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNA.PMID 3022153Read ↗

Multiple processing-defective mutations in a mammalian histone pre-mRNA are suppressed by compensatory changes in U7 RNA both in vivo and in vitro.Semantic proximity Read ↗

Formation of the 3' end of sea urchin U1 small nuclear RNA occurs independently of the conserved 3' box and on transcripts initiated from a histone promoter.Semantic proximity Read ↗

The spacing between functional Cis-elements of U3 snoRNA is critical for rRNA processing.Semantic proximity Read ↗

Functional importance of conserved nucleotides at the histone RNA 3' processing site.Semantic proximity Read ↗

Base pairing between U3 small nucleolar RNA and the 5' end of 18S rRNA is required for pre-rRNA processing.Semantic proximity Read ↗

Evidence for an essential non-Watson-Crick interaction between the first and last nucleotides of a nuclear pre-mRNA intron.Semantic proximity Read ↗

Role of adenine functional groups in the recognition of the 3'-splice-site AG during the second step of pre-mRNA splicing.Semantic proximity Read ↗

Functional base-pairing interaction between highly conserved elements of U3 small nucleolar RNA and the small ribosomal subunit RNA.Semantic proximity Read ↗

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