Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNA.

doi:10.1038/323777a0

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Article

Compensatory mutations suggest that base-pairing with a small nuclear RNA is required to form the 3' end of H3 messenger RNA.

Nature - 1 Jan 2000

Schaufele F, Gilmartin G M, Bannwarth W, Birnstiel M L

Abstract excerpt

Processing of the 3' end of sea urchin H3 histone pre-mRNA requires conserved sequence elements and the presence of U7 snRNA. A mutation in the conserved CAAGAAGA sequence of the H3 pre-mRNA that renders 3' processing of this precursor defective is shown to be suppressed by a compensatory change...

Topics

Animals
Base Sequence
DNA Restriction Enzymes
Histones
Mutation
Nucleic Acid Conformation
Nucleic Acid Hybridization
Nucleic Acid Precursors
Oocytes
RNA Precursors
RNA, Messenger
RNA, Small Nuclear
Sea Urchins
Xenopus

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