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Article

Impaired suppressive activities of human MUTYH variant proteins against oxidative mutagenesis.

World journal of gastroenterology - 21 Dec 2012

Shinmura Kazuya, Goto Masanori, Tao Hong, Matsuura Shun, Matsuda Tomonari, Sugimura Haruhiko

Abstract excerpt

AIM: To investigate the suppressive activity of MUTYH variant proteins against mutations caused by oxidative lesion, 8-hydroxyguanine (8OHG), in human cells. METHODS: p.R154H, p.M255V, p.L360P, and p.P377L MUTYH variants, which were previously found in patients with colorectal polyposis and cancer, were selected for use in this study. Human H1299 cancer cell lines inducibly expressing wild-type (WT) MUTYH (type...

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Share to Adenomatous Polyposis Coli
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23322991
DOI: 10.3748/wjg.v18.i47.6935
PMCID: PMC3531677

Genes

MUTYH

Provenance

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