Genetic Variants Associated with Circulating Fibroblast Growth Factor 23.

doi:10.1681/ASN.2018020192

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Article

Genetic Variants Associated with Circulating Fibroblast Growth Factor 23.

Journal of the American Society of Nephrology : JASN - 1 Oct 2018

Robinson-Cohen Cassianne, Bartz Traci M, Lai Dongbing, Ikizler T Alp, Peacock Munro, Imel Erik A, Michos Erin D, Foroud Tatiana M, Akesson Kristina, Taylor Kent D, Malmgren Linnea, Matsushita Kunihiro, Nethander Maria, Eriksson Joel, Ohlsson Claes, Mellström Daniel, Wolf Myles, Ljunggren Osten, McGuigan Fiona, Rotter Jerome I, Karlsson Magnus, Econs Michael J, Ix Joachim H, Lutsey Pamela L, Psaty Bruce M, de Boer Ian H, Kestenbaum Bryan R

Abstract excerpt

BACKGROUND: Fibroblast growth factor 23 (FGF23), a bone-derived hormone that regulates phosphorus and vitamin D metabolism, contributes to the pathogenesis of mineral and bone disorders in CKD and is an emerging cardiovascular risk factor. Central elements of FGF23 regulation remain incompletely understood; genetic variation may help explain interindividual differences. METHODS: We performed a meta-analysis of...

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PMID: 30217807
DOI: 10.1681/ASN.2018020192
PMCID: PMC6171267

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