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Article

Genome-wide association study for circulating fibroblast growth factor 21 and 23.

Scientific reports - 3 Sept 2020

Chuang Gwo-Tsann, Liu Pi-Hua, Chyan Tsui-Wei, Huang Chen-Hao, Huang Yu-Yao, Lin Chia-Hung, Lin Jou-Wei, Hsu Chih-Neng, Tsai Ru-Yi, Hsieh Meng-Lun, Lee Hsiao-Lin, Yang Wei-Shun, Robinson-Cohen Cassianne, Hsiung Chia-Ni, Shen Chen-Yang, Chang Yi-Cheng

Abstract excerpt

Fibroblast growth factors (FGFs) 21 and 23 are recently identified hormones regulating metabolism of glucose, lipid, phosphate and vitamin D. Here we conducted a genome-wide association study (GWAS) for circulating FGF21 and FGF23 concentrations to identify their genetic determinants. We enrolled 5,000 participants from Taiwan Biobank for this GWAS. After excluding participants with diabetes mellitus and quality...

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Identifiers

PMID: 32884031
DOI: 10.1038/s41598-020-71569-8
PMCID: PMC7471933

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