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Article

FGF23 gene variation and its association with phosphate homeostasis and bone mineral density in Finnish children and adolescents.

Bone - 1 Feb 2015

Pekkinen Minna, Laine Christine M, Mäkitie Riikka, Leinonen Eira, Lamberg-Allardt Christel, Viljakainen Heli, Mäkitie Outi

Abstract excerpt

Fibroblast growth factor 23 (FGF23), a bone-derived hormone, participates in the hormonal bone-parathyroid-kidney axis, which is modulated by PTH, 1,25-dihydroxyvitamin D, plasma phosphate (Pi), and diet. Inappropriately high serum FGF23, seen in certain genetic and acquired disorders, results in urinary phosphate wasting and impaired bone mineralization. This study investigated the impact of FGF23 gene variation...

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Source

Identifiers

PMID: 25445451
DOI: 10.1016/j.bone.2014.10.013

Genes

FGF23
PTH

Variants

rs11063112
rs7955866

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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