Article
Genetic loci influencing kidney function and chronic kidney disease.
Nature genetics - 1 May 2010
Chambers John C, Zhang Weihua, Lord Graham M, van der Harst Pim, Lawlor Debbie A, Sehmi Joban S, Gale Daniel P, Wass Mark N, Ahmadi Kourosh R, Bakker Stephan J L, Beckmann Jacqui, Bilo Henk J G, Bochud Murielle, Brown Morris J, Caulfield Mark J, Connell John M C, Cook H Terence, Cotlarciuc Ioana, Davey Smith George, de Silva Ranil, Deng Guohong, Devuyst Olivier, Dikkeschei Lambert D, Dimkovic Nada, Dockrell Mark, Dominiczak Anna, Ebrahim Shah, Eggermann Thomas, Farrall Martin, Ferrucci Luigi, Floege Jurgen, Forouhi Nita G, Gansevoort Ron T, Han Xijin, Hedblad Bo, Homan van der Heide Jaap J, Hepkema Bouke G, Hernandez-Fuentes Maria, Hypponen Elina, Johnson Toby, de Jong Paul E, Kleefstra Nanne, Lagou Vasiliki, Lapsley Marta, Li Yun, Loos Ruth J F, Luan Jian'an, Luttropp Karin, Maréchal Céline, Melander Olle, Munroe Patricia B, Nordfors Louise, Parsa Afshin, Peltonen Leena, Penninx Brenda W, Perucha Esperanza, Pouta Anneli, Prokopenko Inga, Roderick Paul J, Ruokonen Aimo, Samani Nilesh J, Sanna Serena, Schalling Martin, Schlessinger David, Schlieper Georg, Seelen Marc A J, Shuldiner Alan R, Sjögren Marketa, Smit Johannes H, Snieder Harold, Soranzo Nicole, Spector Timothy D, Stenvinkel Peter, Sternberg Michael J E, Swaminathan Ramasamyiyer, Tanaka Toshiko, Ubink-Veltmaat Lielith J, Uda Manuela, Vollenweider Peter, Wallace Chris, Waterworth Dawn, Zerres Klaus, Waeber Gerard, Wareham Nicholas J, Maxwell Patrick H, McCarthy Mark I, Jarvelin Marjo-Riitta, Mooser Vincent, Abecasis Goncalo R, Lightstone Liz, Scott James, Navis Gerjan, Elliott Paul, Kooner Jaspal S
Abstract excerpt
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute...