Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course.

doi:10.1186/s12974-018-1307-1

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Article

Exome sequencing study in patients with multiple sclerosis reveals variants associated with disease course.

Journal of neuroinflammation - 14 Sept 2018

Gil-Varea Elia, Urcelay Elena, Vilariño-Güell Carles, Costa Carme, Midaglia Luciana, Matesanz Fuencisla, Rodríguez-Antigüedad Alfredo, Oksenberg Jorge, Espino-Paisan Laura, Dessa Sadovnick A, Saiz Albert, Villar Luisa M, García-Merino Juan Antonio, Ramió-Torrentà Lluís, Triviño Juan Carlos, Quintana Ester, Robles René, Sánchez-López Antonio, Arroyo Rafael, Alvarez-Cermeño Jose C, Vidal-Jordana Angela, Malhotra Sunny, Fissolo Nicolas, Montalban Xavier, Comabella Manuel

Abstract excerpt

BACKGROUND: It remains unclear whether disease course in multiple sclerosis (MS) is influenced by genetic polymorphisms. Here, we aimed to identify genetic variants associated with benign and aggressive disease courses in MS patients. METHODS: MS patients were classified into benign and aggressive phenotypes according to clinical criteria. We performed exome sequencing in a discovery cohort, which included 20 MS...

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Identifiers

PMID: 30217166
DOI: 10.1186/s12974-018-1307-1
PMCID: PMC6138928

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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