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Deficit schizophrenia and its features are associated with PON1 Q192R genotypes and lowered paraoxonase 1 (PON1) enzymatic activity: effects on bacterial translocation.

CNS spectrums - 1 Aug 2021

Matsumoto Andressa K, Maes Michael, Supasitthumrong Thitiporn, Maes Annabel, Michelin Ana P, de Oliveira Semeão Laura, de Lima Pedrão João V, Moreira Estefania G, Kanchanatawan Buranee, Barbosa Decio S

Abstract excerpt

BACKGROUND: Primary deficit schizophrenia (DS) is characterized by enduring negative symptoms and represents a qualitatively different disease entity with respect to non-deficit schizophrenia (NDS). No studies investigated the association between the enzyme paraoxonase 1 (PON1) and DS and its phenomenology. METHODS: In this case-control study, Thai women and men, aged 18 to 65 years, were divided in DS (n = 40)...

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PMID: 32638685
DOI: 10.1017/S1092852920001388

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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