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Article

RNA targets of wild-type and mutant FET family proteins.

Nature structural & molecular biology - 13 Nov 2011

Hoell Jessica I, Larsson Erik, Runge Simon, Nusbaum Jeffrey D, Duggimpudi Sujitha, Farazi Thalia A, Hafner Markus, Borkhardt Arndt, Sander Chris, Tuschl Thomas

Abstract excerpt

FUS, EWSR1 and TAF15, constituting the FET protein family, are abundant, highly conserved RNA-binding proteins with important roles in oncogenesis and neuronal disease, yet their RNA targets and recognition elements are unknown. Using PAR-CLIP, we defined global RNA targets for all human FET proteins and two ALS-causing human FUS mutants. FET members showed similar binding profiles, whereas FUS mutants showed a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22081015
DOI: 10.1038/nsmb.2163
PMCID: PMC3230689

Genes

FUS
EWSR1
TAF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RNA targets of wild-type and mutant FET family proteins.PMID 22081015Read ↗

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