Article
Identification of ter94, Drosophila VCP, as a strong modulator of motor neuron degeneration induced by knockdown of Caz, Drosophila FUS.
Human molecular genetics - 1 Jul 2014
Azuma Yumiko, Tokuda Takahiko, Shimamura Mai, Kyotani Akane, Sasayama Hiroshi, Yoshida Tomokatsu, Mizuta Ikuko, Mizuno Toshiki, Nakagawa Masanori, Fujikake Nobuhiro, Ueyama Morio, Nagai Yoshitaka, Yamaguchi Masamitsu
Abstract excerpt
In humans, mutations in the fused in sarcoma (FUS) gene have been identified in sporadic and familial forms of amyotrophic lateral sclerosis (ALS). Cabeza (Caz) is the Drosophila ortholog of human FUS. Previously, we established Drosophila models of ALS harboring Caz-knockdown. These flies develop locomotive deficits and anatomical defects in motoneurons (MNs) at neuromuscular junctions; these phenotypes indicate...
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