Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

In silico screening and molecular dynamics simulation of disease-associated nsSNP in TYRP1 gene and its structural consequences in OCA3.

BioMed research international - 1 Jan 2013

Kamaraj Balu, Purohit Rituraj

Abstract excerpt

Oculocutaneous albinism type III (OCA3), caused by mutations of TYRP1 gene, is an autosomal recessive disorder characterized by reduced biosynthesis of melanin pigment in the hair, skin, and eyes. The TYRP1 gene encodes a protein called tyrosinase-related protein-1 (Tyrp1). Tyrp1 is involved in m...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Albinism, Oculocutaneous
Share to Computer Simulation
Share to Membrane Glycoproteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Molecular Dynamics Simulation

Share to Mutant Proteins

Share to Oxidoreductases

Share to Protein Structure, Secondary

Share to Software

Source

Open in PubMed Open full text

Identifiers

PMID: 23862152
DOI: 10.1155/2013/697051
PMCID: PMC3703794

Genes

TYRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23862152-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

In silico screening and molecular dynamics simulation of disease-associated nsSNP in TYRP1 gene and its structural consequences in OCA3.PMID 23862152Read ↗

Computational screening of disease-associated mutations in OCA2 gene.Semantic proximity Read ↗

Mutational analysis of TYR gene and its structural consequences in OCA1A.Semantic proximity Read ↗

Computational analysis of the deleterious non-synonymous single nucleotide polymorphisms (nsSNPs) in TYR gene impacting human tyrosinase protein and the protein stability.Semantic proximity Read ↗

In silico screening of deleterious single nucleotide polymorphisms (SNPs) and molecular dynamics simulation of disease associated mutations in gene responsible for oculocutaneous albinism type 6 (OCA 6) disorder.Semantic proximity Read ↗

Mutational Analysis on Membrane Associated Transporter Protein (MATP) and Their Structural Consequences in Oculocutaeous Albinism Type 4 (OCA4)-A Molecular Dynamics Approach.Semantic proximity Read ↗

Computational analysis of histidine mutations on the structural stability of human tyrosinases leading to albinism insurgence.Semantic proximity Read ↗

Computational identification of pathogenic associated nsSNPs and its structural impact in UROD gene: a molecular dynamics approach.Semantic proximity Read ↗

In vitro characterization of the intramelanosomal domain of human recombinant TYRP1 and its oculocutaneous albinism type 3-related mutant variants.Semantic proximity Read ↗

Genetic mutations disrupt the coordinated mode of tyrosinase's intra-melanosomal domain.Semantic proximity Read ↗

Analysis of Immobilized Protein Unfolding and Molecular Dynamics Shows How pH, Glycosylation, and OCA3-Related Variants Influence Tyrp1's Stability and Function.Semantic proximity Read ↗

Two novel tyrosinase (TYR) gene mutations with pathogenic impact on oculocutaneous albinism type 1 (OCA1).Semantic proximity Read ↗

Structure and Function of Human Tyrosinase and Tyrosinase-Related Proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.