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Article

Deciphering the loss of metal binding due to mutation D83G of human SOD1 protein causing FALS disease.

International journal of biological macromolecules - 1 Feb 2018

Srinivasan E, Rajasekaran R

Abstract excerpt

Mutations in Cu/Zn superoxide dismutase 1 (SOD1) protein are found to be the causative factor, behind the majority of familial amyotrophic later sclerosis (FALS) cases. The mutations particularly on the metal (Zn) binding residues are found to increase the disease onset in the individuals suffering from FALS, while the presence of the metal ion (Zn) is essential for the catalytic activity and retaining the...

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Identifiers

PMID: 28899654
DOI: 10.1016/j.ijbiomac.2017.09.019

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SOD1

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