Article
Association between 14 bp insertion/deletion HLA-G functional polymorphism and insulin resistance in a cohort of Italian children with obesity.
Pediatric diabetes - 1 Dec 2018
Marzuillo Pierluigi, Bellini Giulia, Punzo Francesca, Di Sessa Anna, Guarino Stefano, Umano Giuseppina R, Toraldo Roberto, Miraglia Del Giudice Emanuele, Rossi Francesca
Abstract excerpt
BACKGROUND: The non-classical HLA-class I molecule-g (HLA-G) gene shows a deletion/insertion (del/ins) polymorphism of a 14-base-pair sequence (14 bp) in the exon 8 at the 3' untranslated region. The presence of the 14 bp insertion allele has been associated to lower soluble HLA-G protein production, a protein with anti-inflammatory activities. So far, no studies have investigated the relationship between HLA-G...
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