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Article

Homozygous AA Genotype of IL-17A and 14-bp Insertion Polymorphism in HLA-G 3'UTR Are Associated with Increased Risk of Gestational Diabetes Mellitus.

International journal of environmental research and public health - 22 Feb 2025

de Souza Amaxsell Thiago Barros, Lucas Cecília Rodrigues, de Carvalho Kleyton Thiago Costa, Neta Antonia Pereira Rosa, Bernardes-Oliveira Emanuelly, Camargo Juliana Dantas de Araújo Santos, Luchessi André Ducati, Cobucci Ricardo Ney, Crispim Janaina Cristiana de Oliveira

Abstract excerpt

Gestational diabetes mellitus (GDM) is a common pregnancy complication characterized by hyperglycemia and insulin resistance, with unclear genetic mechanisms. The specific involvement of proinflammatory cytokines, including IL-17A, and the immuno-tolerogenic HLA-G remains poorly understood in GDM. We aimed to explore the associations of three polymorphisms, IL-17A -197G>A (rs2275913), IL-17RA -947A>G (rs4819554),...

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Identifiers

PMID: 40238306
DOI: 10.3390/ijerph22030327
PMCID: PMC11941881

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