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Article

Rapid, complete and large-scale generation of post-mitotic neurons from the human LUHMES cell line.

Journal of neurochemistry - 1 Dec 2011

Scholz Diana, Pöltl Dominik, Genewsky Andreas, Weng Matthias, Waldmann Tanja, Schildknecht Stefan, Leist Marcel

Abstract excerpt

We characterized phenotype and function of a fetal human mesencephalic cell line (LUHMES, Lund human mesencephalic) as neuronal model system. Neurodevelopmental profiling of the proliferation stage (d0, day 0) of these conditionally-immortalized cells revealed neuronal features, expressed simultaneously with some early neuroblast and stem cell markers. An optimized 2-step differentiation procedure, triggered by...

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PMID: 21434924
DOI: 10.1111/j.1471-4159.2011.07255.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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