Article
miR-34a regulates cell proliferation, morphology and function of newborn neurons resulting in improved behavioural outcomes.
Cell death & disease - 29 Jan 2015
Mollinari C, Racaniello M, Berry A, Pieri M, de Stefano M C, Cardinale A, Zona C, Cirulli F, Garaci E, Merlo D
Abstract excerpt
miR-34a is involved in the regulation of the fate of different cell types. However, the mechanism by which it controls the differentiation programme of neural cells remains largely unknown. Here, we investigated the role of miR-34a in neurogenesis and maturation of developing neurons and identified Doublecortin as a new miR-34a target. We found that the overexpression of miR-34a in vitro significantly increases...
Topics
- Animals
- Base Sequence
- Behavior, Animal
- Bromodeoxyuridine
- Cell Differentiation
- Cell Movement
- Cell Proliferation
- Cell Shape
- Cells, Cultured
- Cerebral Cortex
- Cognition