Article
Role of interleukin 1-beta in the inflammatory response in a fatty acid amide hydrolase-knockout mouse model of Alzheimer's disease.
Biochemical pharmacology - 1 Nov 2018
Aparicio Noelia, Grande M Teresa, Ruiz de Martín Esteban Samuel, López Alicia, Ruiz-Pérez Gonzalo, Amores Mario, Vázquez Carmen, Martínez-Relimpio Ana M, Pazos M Ruth, Cravatt Benjamin F, Tolón Rosa M, Romero Julián
Abstract excerpt
The search for novel therapies for the treatment of Alzheimer's disease is an urgent need, due to the current paucity of available pharmacological tools and the recent failures obtained in clinical trials. Among other strategies, the modulation of amyloid-triggered neuroinflammation by the endocannabinoid system seems of relevance. Previous data indicate that the enhancement of the endocannabinoid tone through...
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