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Article

The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes.

Scientific reports - 5 Sept 2018

Emperle Max, Dukatz Michael, Kunert Stefan, Holzer Katharina, Rajavelu Arumugam, Jurkowska Renata Z, Jeltsch Albert

Abstract excerpt

The DNA methyltransferase DNMT3A R882H mutation is observed in 25% of all AML patients. DNMT3A is active as tetramer and the R882H mutation is located in one of the subunit/subunit interfaces. Previous work has reported that formation of mixed wildtype/R882H complexes leads to a strong loss of catalytic activity observed in in vitro DNA methylation assays (Russler-Germain et al., 2014, Cancer Cell 25:442-454). To...

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Identifiers

PMID: 30185810
DOI: 10.1038/s41598-018-31635-8
PMCID: PMC6125428

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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