Article
Identification and replication of RNA-Seq gene network modules associated with depression severity.
Translational psychiatry - 5 Sept 2018
Le Trang T, Savitz Jonathan, Suzuki Hideo, Misaki Masaya, Teague T Kent, White Bill C, Marino Julie H, Wiley Graham, Gaffney Patrick M, Drevets Wayne C, McKinney Brett A, Bodurka Jerzy
Abstract excerpt
Genomic variation underlying major depressive disorder (MDD) likely involves the interaction and regulation of multiple genes in a network. Data-driven co-expression network module inference has the potential to account for variation within regulatory networks, reduce the dimensionality of RNA-Seq data, and detect significant gene-expression modules associated with depression severity. We performed an RNA-Seq...
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