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Article

MICA and NLRP3 gene polymorphisms interact synergistically affecting the risk of ankylosing spondylitis.

Immunologic research - 1 Feb 2024

Fernández-Torres Javier, Zamudio-Cuevas Yessica, Ruiz-Dávila Xiadani, López-Macay Ambar, Martínez-Flores Karina

Abstract excerpt

Ankylosing spondylitis (AS) is an autoinflammatory disease that affects the sacroiliac joints, causing stiffness and pain in the back. MICA is a ligand of the NKG2D receptor, and an increase in its expression affects the immune response in various diseases. NLRP3 is a multiprotein complex that promotes the release of IL-1β, but its role in AS has been minimally explored. The objective of this study was to analyze...

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Identifiers

PMID: 37665559
DOI: 10.1007/s12026-023-09419-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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