Article
[Non-MHC susceptibility genes in Japanese subjects with insulin-dependent diabetes mellitus (IDDM)].
Nihon rinsho. Japanese journal of clinical medicine - 1 Oct 1994
Matsumoto C, Awata T
Abstract excerpt
Genetic factors clearly contribute to the development of autoimmune destruction of pancreatic beta cell in IDDM. The HLA class II genes have an important role in the pathogenesis of Japanese IDDM as they do in Caucasians. Particular HLA class II alleles and haplotypes contribute to the IDDM susceptibility/resistance in Japanese. In the 5' insulin gene polymorphism, the shorter insertion (class 1 allele) is...
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