Article
Phosphorylation state of Ser165 in α-tubulin is a toggle switch that controls proliferating human breast tumors.
Cellular signalling - 1 Dec 2018
Markovsky Ela, de Stanchina Elisa, Itzkowitz Aryeh, Haimovitz-Friedman Adriana, Rotenberg Susan A
Abstract excerpt
Engineered overexpression of protein kinase Cα (PKCα) is known to phosphorylate Ser165 in α-tubulin resulting in stimulated microtubule dynamics and cell motility, and activation of an epithelial-mesenchymal transition (EMT) in non-transformed human breast cells. Here it is shown that endogenous phosphorylation of native α-tubulin in two metastatic breast cell lines, MDA-MB-231-LM2-4175 and MDA-MB-468 is detected...
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