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Article

Protein kinase Cα mediates erlotinib resistance in lung cancer cells.

Molecular pharmacology - 1 May 2015

Abera Mahlet B, Kazanietz Marcelo G

Abstract excerpt

Overexpression and mutational activation of the epidermal growth factor receptor (EGFR) plays an important role in the pathogenesis of non-small cell lung cancer (NSCLC). EGFR tyrosine-kinase inhibitors (TKIs) are given as a primary therapy for advanced patients with EGFR-activating mutations; however, the majority of these tumors relapse and patients eventually develop resistance to TKIs. To address a potential...

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Source

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Identifiers

PMID: 25724832
DOI: 10.1124/mol.115.097725
PMCID: PMC4407729

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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