Article
Critical role of phosphorylation of serine 165 of YBX1 on the activation of NF-κB in colon cancer.
Oncotarget - 6 Oct 2015
Prabhu Lakshmi, Mundade Rasika, Wang Benlian, Wei Han, Hartley Antja-Voy, Martin Matthew, McElyea Kyle, Temm Constance J, Sandusky George, Liu Yunlong, Lu Tao
Abstract excerpt
Y-box binding protein 1 [YBX1] is a multifunctional protein known to facilitate many of the hallmarks of cancer. Elevated levels of YBX1 protein are highly correlated with cancer progression, making it an excellent marker in cancer. The connection between YBX1 and the important nuclear factor κB [NF-κB] has never been reported. Here, we show that overexpression of wild type YBX1 [WT-YBX1] activates NF-κB,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.