Article

The testis protein ZNF165 is a SMAD3 cofactor that coordinates oncogenic TGFβ signaling in triple-negative breast cancer

2020-04-05

Abstract excerpt

<h4>ABSTRACT</h4> Cancer/testis (CT) antigens are proteins whose expression is normally restricted to germ cells yet aberrantly activated in tumors, where their functions remain relatively cryptic. Here we report that ZNF165, a CT antigen frequently expressed in triple-negative breast cancer (TNBC), associates with SMAD3 to modulate transcription of transforming growth factor β (TGFβ)-dependent genes and thereby...

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Literature Corpus work: 882e09a0-8de0-513e-b50f-1e0bf71ccd63
DOI: 10.1101/2020.04.04.025742

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